Tetrahydrocannabinol (THC) is the first psychoactive element of the Cannabis plant. The perfect-studied cannabinoids embody tetrahydrocannabinol (THC), cannabidiol (CBD), and ejuiceuk cannabinol (CBN). CBN interacts with other neurotransmitter methods (e.g., dopaminergic, serotonergic), requiring higher doses for physiologic results like mild sedation in comparison with THC. Cannabinol (CBN) is a mildly psychoactive cannabinoid appearing as a low-affinity partial agonist at CB1 and CB2 receptors.

CBD has low affinity for vapekituk CB1 and CB2 receptors however acts as an oblique antagonist of cannabinoid agonists. Cannabis might provide restricted relief for some Parkinson's disease (PD) symptoms, akin to pain, sleep issues, or ezigarettenbasen anxiety, primarily based on small human research (2023-2024, 10-50 individuals), nevertheless it doesn't improve motor signs like tremors or stiffness (no important change in Unified Parkinson's Disease Ranking Scale scores). A subpopulation of microglia within the human cerebellum expresses CB2.

CB1 can also be discovered in the human anterior vapekituk eye and retina. Perrottetinene, a moderately psychoactive cannabinoid, ezigarettepreis is found in Radula varieties. This channel has additionally been found to be involved within the motion of anaesthetics equivalent to chloroform, halothane and propofol. The closest relative is the cold and menthol activated TRPM8 ion channel. It was established in 2021 that TRPC5 is a component of the dental cold sensing system. While TRPM2 shouldn't be chilly delicate it's activated by heat.

Transient receptor potential cation channel, subfamily M, member 2, also called TRPM2, is a protein that in humans is encoded by the TRPM2 gene.

Tan CH, McNaughton PA (2016). "The TRPM2 ion channel is required for sensitivity to warmth". Trimpe DM, Byrd-Jacobs CA (2016). "Patterns of olfactory bulb neurogenesis within the adult zebrafish are altered following reversible deafferentation". Gonçalves JT, Schafer ST, Gage FH (2016). "Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior".

Hentig JT, rabattvape Byrd-Jacobs CA (2016-08-31). "Exposure to Zinc Sulfate Ends in Differential Effects on Olfactory Sensory Neuron Subtypes in Adult Zebrafish".